scale up calculation in high shear mixer

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  • Evaluating Scale-Up Rules of a High-Shear Wet Granulation ...

    For the selected formulation the lab scale Mi-Pro high shear mixers with different bowl volumes could be used to determine the optimal process parameters and to scale up

  • Application of the Discrete Element Method to Scale-Up of ...

    Scale-up of high-shear granulation has been an important yet challenging issue in the pharmaceutical industries. A discrete element method (DEM) is a promising tool for the rational design and scale-up of high-shear granulation, because the internal properties such as particle flow and stress field, which are hard to measure experimentally, can be investigated. This

  • Granulation: Endpoint Determination and Scale-Up

    Scale-up in fixed bowl mixer-granulators has been studied by Ray Rowe and Mike Cliffs group using the classical dimensionless numbers of Newton (Power), Reynolds and Froude to predict end-point in geometrically similar high-shear Fielder PMA25, 100, and 600 liter machines [64].

  • Scale up of High Shear Mixers

    Scale up of High Shear Rotor-Stator Mixers In virtually any application, scale up is a critical process that impacts your business in a multitude of ways, from proper planning of plant floor design and equipment configuration, to operating procedures, to the net operating-and capital-cost impact on the bottom line.

  • CHAPTER 9. AGITATION AND MIXING

    Mixing: It is the random distribution, into and through one another, of two or more initially separate phases ... Propellers (high-speed, low viscosity) Turbines (Moderate viscosity) High-efficiency impellers Three-blade marine ... SCALE UP

  • (PPT) Scale up by CFD | Jayant Patil - Academia

    27 CFD Applications Mixing (General) Determine uniformity of solution through mixing studies Examine the shear forces throughout the mixing tank and effect on the product 28 CFD Helping Scale-up Issues Scale-up Philosophy Geometry of the bioreactor scaled from 2, 15, 100, 400, 1600 L to 20,000 L all the same aspect ratio ...

  • Successful Scale-Up of High Shear Batch and In-line Mixers

    with the scale-up of mixers from a 3 liter beaker right up to a 1000 gallon (or larger) production vessel. Scale-up of high shear mixers is a particularly challenging issue as many the variables typically observed with low speed agitators do not apply.

  • High Shear Mixer Scale-Up - Silverson Mixers

    Pilot Scale Batch Mixers. Laboratory In-Line Mixers. Batch Mixers. Ultramix Mixers. In-Line Mixers. In-Line Ultra Hygienic Mixers. High Viscosity In-Line Mixers. Silverson Mixer Homogenisers. Flashmix Powder/Liquid Mixers.

  • Assessing Mixing Sensitivities for Scale-up

    Oct 20, 2014· Example 2: Scale-up of an Energetic, Scale-down of the Mixing The reactions to form intermediate 2 are very rapid intermediate 1 is never seen in the reaction. Intermediate 2 is above the solubility limit for majority of the reaction. As the reaction

  • (PDF) 'High Shear' Mixers | Gerard Hawkins - Academia

    To achieve economical batch times rotor to vessel diameter ratios as high as 0.33 have been required. Mixers for these duties should be scaled up from trials on small-scale mixers. The small scale impeller should have the same rotor to stator gap, blade angle and tip speed as that proposed for the larger scale.

  • Wet granulation in laboratory scale high shear mixers ...

    Wet granulation in laboratory scale high shear mixers: Effect of binder properties T.M. Chitua,, D. Oulahnaa, M. Hematib a RAPSODEE Research Centre, UMR EMAC-CNRS 2392, Ecole des Mines d'Albi-Carmaux, Campus Jarlard, 81013 Albi, France b Laboratoires de Génie Chimique UMR-CNRS 5503, ENSIACET, INPT, BP 1301, 5 Rue Paulin Talabot, 31106 Toulouse Cedex 1, France

  • SCALE-UP OF MIXING SYSTEMS

    SCALE-UP OF MIXING SYSTEMS The calculation of power requirements for agitation is only a part of the mixer design. In any mixing problem, there are several defined objectives such as the time required for blending two immiscible liquids, rates of heat transfer from a heated jacket per unit volume of

  • Agitation Scaleup Calculation

    Scale-up Ratio, R = (V2/V1) 1/3. R = 10.0. Shaft speed scaling is done based on following relation: N2 = N1 . (1/R) n. The value of n, called the scaling exponent, depends on the physical result to be scaled. Sacle-up for Equal Reynold's No. Tip Speed Power /

  • High Shear Granulation Scale Up | Continuum Mechanics ...

    High Shear Granulation Scale-Up. Mohsen Sadatrezaei Pharm.D. Geneva Pharmaceutical Dayton, NJ ntroduction et granulation is used to improve . . . FIow CompressibiIity Bio-avaiIabiIity Homogeneity EIectrostatic properties StabiIity Densification AggIomeration Shearing and compressing action of the impeIIer Mixing, granuIation and wet massing PossibiIity of

  • Evaluating scale-up rules of a high-shear wet granulation ...

    Abstract. This work aimed to evaluate the commonly used scale-up rules for high-shear wet granulation process using a microcrystalline cellulose-lactose-based low drug loading formulation. Granule properties such as particle size, porosity, flow, and tabletability, and tablet dissolution were compared across scales using scale-up rules based on ...

  • Evaluating Scale-Up Rules of a High-Shear Wet Granulation ...

    For the selected formulation the lab scale Mi-Pro high shear mixers with different bowl volumes could be used to determine the optimal process parameters and to scale up

  • Graceful Scale-Up of Mixing Systems Make it Happen for You

    On the other hand, in an inline high shear mixer set-up, the mixing process is also tightly controlled in the sense that the number of passes through the high-shear zone can be monitored with confidence. Inline HSMs are practical solutions for tanks that are already equipped with low-shear, gentle-mixing agitators. Operators can add an inline ...

  • PPT High Shear Granulation Scale-Up PowerPoint ...

    Granule growth in high shear mixer. This demonstrates the characteristic features of. the agglomeration of insoluble, cohesive powders. in high shear mixers. The growth rate is very. sensitive to the amount of liquid phase and to. processing conditions, in particular the impeller. rotation speed and processing time. 9.

  • Scale-up effects on flow patterns in the high shear mixing ...

    Keywords: high shear mixer, cohesive powders, scale-up, mixing regimes 1 Introduction High shear mixers, also known as high intensity mixers (Paul et al., 2003), are widely used for the powder processing. They can be used for simple mixing, in particular of cohesive materials, since

  • Laboratory High Shear Inline Mixers for Scale-up | Bematek

    Laboratory High Shear Inline Mixers. The Bematek Laboratory LY dynamic mixer system was developed for R&D purposes and the complex task of scale-up in emulsifying and dispersing applications. These systems have features that address factors such as ergonomics, ease of use and flexibility in throughput demands.

  • Scale-Up of High Shear Granulation Based on the Internal ...

    tween the measured stress and several scale-up parameters was investigated. The analysis of the scale-up characteristics of the high shear granulation was conducted and a practical method for the scale-up was proposed. Experimental Apparatus Figure 1 shows a schematic diagram of the experimental ap-paratus. Vertical high shear mixers (SPG-10 ...

  • Scale-up Basics for Fomulators and Process Engineers

    Jul 09, 2013· A number of authors have written about scale-up processes for personal care products. One commonly referenced article by Dickey describes the importance of consistent tank geometry and provides a few approaches to calculating scalable mixer speeds. 1 Similarly, Yacko has presented on mixing and heat transfer considerations, as well as specific parameters and

  • Dem investigation of horizontal high shear mixer flow ...

    mixing, coalescence, granule consolidation as well as breakage. There are several high shear mixer configurations, categorised as horizontal or vertical shaft mixers and the latter can be either top- or bottom-driven [1]. In high shear granulation, maintaining the targeted product attributes upon scale-up to larger

  • Process Engineering | Don't get mixed up by scale-up ...

    Aug 04, 2005· The recommended approach for doing non-geometric scale-up is as follows: 1. Calculate the laboratory- or pilot-plant-scale values for the mixing variables listed in the sidebar. 2. Do a geometric-similarity scale-up to the large-scale tank diameter. Use a criterion such as tip speed to set the large-scale speed.

  • Better understanding boosts mixer scale-up

    Apr 10, 2008· Again, results from these studies are being utilized to streamline development processes and as an aid to scale-up but little of the research has found its way into the public domain. To some extent this is understandable because the market for high shear mixing equipment is relatively small and highly competitive.

  • High Shear Mixing FAQs - Silverson Mixers

    A: Silverson High Shear Batch mixers are ideal for volumes of up to 400 gallons, depending on viscosity. While we do offer Batch machines for much larger capacities, in general beyond this point an In-Line mixer is often the most efficient and economical option. This is because the In-Line mixers energy is concentrated on the small volume within the mixing chamber at any given moment ...

  • Dem investigation of horizontal high shear mixer flow ...

    mixing, coalescence, granule consolidation as well as breakage. There are several high shear mixer configurations, categorised as horizontal or vertical shaft mixers and the latter can be either top- or bottom-driven [1]. In high shear granulation, maintaining the targeted product attributes upon scale-up

  • Design of Large Scale Mixer Settlers in SX Solvent ...

    Feb 02, 2017· The problem of high shear in the mixer also causing the formation of very small droplets and resulting in high solvent losses was one of the most important factors affecting the choice of impeller. A number of plants operating in the metallurgical field were known to have relatively high solvent losses and an effort was made to design a mixer ...

  • MULTI-SCALE MODELING OF HIGH-SHEAR GRANULATION

    Jan 15, 2015· Purdue University Purdue e-Pubs Open Access Dissertations Theses and Dissertations January 2015 MULTI-SCALE MODELING OF HIGH-SHEAR GRANULATION Daniel A. Pohlman

  • High Shear Mixers - SlideShare

    Oct 16, 2013· High Shear Mixers 1. GBH Enterprises, Ltd. Process Engineering Guide: GBHE-PEG-MIX-709 'High Shear' Mixers Information contained in this publication or as otherwise supplied to Users is believed to be accurate and correct at time of going to press, and is given in good faith, but it is for the User to satisfy itself of the suitability of the information for its own particular purpose.

  • HIGH SHEAR WET GRANULATION: PROCESS

    Moreover, scale-up of high shear granulators is still difficult to perform. The present research mainly focuses on the high shear wet granulation of pharmaceutical powders. Particularly, this research aims at closing the gap in understanding the role of ... CHAPTER 6 - Predicting scale up effects on flow pattern in high shear mixing of cohesive ...

  • BenchMix Lab Mixer | Benchtop Mixing | Admix

    BenchMix Benchtop Lab Mixers. The BenchMix is a benchtop lab mixer specifically designed for product development, simulation and scale up. The BenchMix provides predictable, repeatable results from the development lab to full production when scaling up to an Admix high shear production size mixer we back this with our process assurance ...

  • Assessing Mixing Sensitivities for Scale-up

    Oct 20, 2014· Example 2: Scale-up of an Energetic, Scale-down of the Mixing The reactions to form intermediate 2 are very rapid intermediate 1 is never seen in the reaction. Intermediate 2 is above the solubility limit for majority of the reaction. As the reaction is done within the meta-stable zone solids can form.

  • Scale-up Basics for Fomulators and Process Engineers

    Jul 09, 2013· A number of authors have written about scale-up processes for personal care products. One commonly referenced article by Dickey describes the importance of consistent tank geometry and provides a few approaches to calculating scalable mixer speeds. 1 Similarly, Yacko has presented on mixing and heat transfer considerations, as well as specific parameters and variables for cosmetic

  • Scale-up of High-Shear Mixer Granulators

    High-shear mixer granulators are typically found in the pharmaceutical and detergent industries, and are capable of reducing the processing time and produc- ing granules with high strength and density. One of the most important challenges of granula- tion technology is process scale-up5-8).

  • Scaling Up a Rotor-Stator Homogenization Process | Blog ...

    Mar 05, 2019· Due to this, many manufacturers provide shear numbers or curves based on real testing or complex calculations, which will help when scaling up. For example, below is a section of a shear table for a Pro Scientific 20mm probe (the first column is RPM). The numbers are derived from a formula that takes into account a variety of factors, including ...

  • Ultra High Shear Mixing Technology 08242007

    in a 2,000-gal. tank, the material requires mixing under high shear to deagglomerate and disperse the clay so that it develops its thixotropic properties. An initial test on the benchtop reached the specified endpoint (defined in this case as target viscosity) in 30 minutes. A scale up calculation based solely on mixer flow rate suggested that a

  • Mix Small, Think Big: Practical Tips for Mixing Scale-Up

    High-Shear Mixers Bench-top high-shear mixers can pro-cess batch volumes as low as 1 l using interchangeable rotor/stator heads, sawtooth dispersers and propeller blades. A special micro-rotor/stator attachment is designed for even smaller batches in the range of 50-500 ml. Laboratory inline rotor/stators are also available. Multi-Shaft Mixers

  • Wet Granulation: End-Point Scale-Up

    10 liter laboratory scale mixer at its lowest speed settings can reach the Froude numbers of all other mixers, except one. These considerations can be useful for planning a scale-up or technology transfer operation. Fig. 2. The range of Froude numbers for Fielder PMA high-shear mixers. -theorem (Buckingham) The so-called -theorem or Buckingham ...

  • How to Scale-Up Mixing Processes in Non-Newtonian Fluids

    These fluids are either shear-thinning or shear-thicken-ing i.e., their apparent viscosity, µ a, decreases (shear-thinning) or increases (shear-thickening) with the shear rate, γ. This article describes the relationships that must be understood in order to scale-up fluid mixing processes in non-Newtonian power-law fluids. The ...

  • Scale-up of High-Shear Mixer Granulators

    in the past to systematically study the scale-up of high-shear granulation processes and its effect on product characteristics and functionality. Most of the reports in the literature have focused on the mecha-Scale-up of High-Shear Mixer Granulators N. Rahmanian, B.H. Ng, A. Hassanpour, Y.L. Ding, S.J. Antony, X.D. Jia and M. Ghadiri ...

  • Powder blending scaleup - SlideShare

    Sep 05, 2015· 9/5/2015 49 Scale up of Powder Blending March 2014 49 of 50 Tehran University of Medical Sciences School of Pharmacy some simple guidelines that can help through the scale-up Make sure that changes in scale have not changed the dominant mixing mechanism in the blender (i.e., convective to dispersive) Number of revolutions is a key parameter ...

  • SCALE-UP OF MIXING SYSTEMS

    SCALE-UP OF MIXING SYSTEMS The calculation of power requirements for agitation is only a part of the mixer design. In any mixing problem, there are several defined objectives such as the time required for blending two immiscible liquids, rates